A statement from St Charles County police confirmed officers responded to a medical emergency at around 12.40pm today.
A statement read: "Inside the home, first responders observed an unresponsive man and immediately administered lifesaving techniques. Unfortunately, the 90-year-old man could not be revived and was pronounced deceased at 1.26 pm.
"The St Charles County Police Department sadly confirms the death of Charles Edward Anderson Berry Sr., better known as legendary musician Chuck Berry.
"The family requests privacy during this time of bereavement."
Chuck was well known for hit songs including Maybellene, Roll Over Beethoven, Rock and Roll Music and Johnny B. Goode.